![]() ![]() The standard intraoperative diagnostic approach used now involves taking brain tissue, freezing it, and examining it under a microscope. "The ability to determine intraoperative molecular diagnosis in real time, during surgery, can propel the development of real-time precision oncology," Yu added. Knowing a tumor's molecular identity during surgery is also valuable because certain tumors benefit from on-the-spot treatment with drug-coated wafers placed directly into the brain at the time of the operation, Yu said. Our tool overcomes this challenge by extracting thus-far untapped biomedical signals from frozen pathology slides," said study senior author Kun-Hsing Yu, assistant professor of biomedical informatics in the Blavatnik Institute at HMS. ![]() "Right now, even state-of-the-art clinical practice cannot profile tumors molecularly during surgery. Likewise, removing too little when the tumor is highly aggressive may leave behind malignant tissue that can grow and spread quickly. Removing too much when the tumor is less aggressive can affect a patient's neurologic and cognitive function. Knowing a tumor's molecular type enables neurosurgeons to make decisions such as how much brain tissue to remove and whether to place tumor-killing drugs directly into the brain - while the patient is still on the operating table.Ī report on the work, led by Harvard Medical School researchers, is published July 7 in the journal Med.Īccurate molecular diagnosis - which details DNA alterations in a cell - during surgery can help a neurosurgeon decide how much brain tissue to remove. ![]()
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